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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Effectiveness Of Vaccine While On Alcalabrutinib. ?

Effectiveness Of Vaccine While On Alcalabrutinib. ?

I'm currently on Alcalabrutinib (Calquence) for CLL. All my bloodwork shows I'm in normal ranges for WBC, RBC, Hemoglobin, as well as other indicators and am considered in remission for 6 months. I've had both Pfizer vaccine shots 60 days ago with no side effects or issues. After an antibodies test 4 weeks after my second shot, my specialist claims my efficacy is 'less than robust' against COVID 19. Test results were: Anti-SARS-CoV-2 Spike Protein IgG Index: 0.02 S/CO std range: 0.00 -… read more

A MyLeukemiaTeam Member said:

So, since my post 6 mos ago, I still have no antibodies. I have learned that taking oral drugs like Imbruvica and Calquence for CLL causes the vaccines to become virtually ineffective. Even had the booster in August as soon as it was available. In September I contracted Covid from a golf outing in Indiana (no mask or vaccine mandate state). My oncologist ordered the Monoclonal antibodies infusion for me immediately. I came out of it ok and feel great today, though I'm told I still likely have no effective antibodies. Still masking indoors but not for outdoor activities or with family. So far, so good.

posted 10 months ago
A MyLeukemiaTeam Member said:

Latest test (9/20) still high for antibodies.

posted 11 months ago
A MyLeukemiaTeam Member said:

I’m now being tested monthly for antibodies (getting tested today) in order to determine the need for a booster shot. I believe the additional Moderna shots I received in April and May after testing low with the Pfizer shots acted in the same way a booster does so we’ll see how long this high response continues. Once again I’m not currently on any treatment for my CLL.

posted 11 months ago
A MyLeukemiaTeam Member said:

You say, “they want me to get the vaccine.” If by “they” you mean your doctor(s), then follow their advice.

posted about 1 year ago
A MyLeukemiaTeam Member said:

Hmmmm I would play it safe for now.

posted about 1 year ago
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