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Tibsovo is a prescription medication approved by the Food and Drug Administration (FDA) to treat relapsed or refractory acute myeloid leukemia (AML) that has tested positive for a mutation in the isocitrate dehydrogenase-1 (IDH1) gene. Tibsovo may also be referred to by its drug name, Ivosidenib.

Tibsovo is the first drug in a new class called IDH1 inhibitors. Tibsovo is believed to work by interfering with the ability of leukemia cells to release stored energy.

How do I take it?
Tibsovo is taken orally once a day.

Tibsovo comes in the form of a tablet.

Side effects
The FDA-approved label for Tibsovo lists common side effects including fatigue, fever, cough, rash, joint pain, mouth sores, nausea, diarrhea, constipation, trouble breathing, and edema (swelling).

Rare but serious side effects listed for Tibsovo include fetal harm in pregnant women and differentiation syndrome, a life-threatening condition that causes trouble breathing and hypotension (low blood pressure). Tibsovo can also cause changes in heart rhythm and Guillain-Barré Syndrome, a condition in which the immune system attacks the nerves, causing weakness and potentially fatal paralysis of the muscles needed for breathing.

For more details about this treatment, visit:

Tibsovo – Agios

AML: Relapsed and Refractory – Leukemia and Lymphoma Society

Tibsovo (Ivosidenib) for Leukemia Questions

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