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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

He has CMML. And may also have Lymphoma.

November 20, 2025
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A MyLeukemiaTeam Member

The spleen is the organ to remove `unwanted things in the body? I just learned my spleen was "enlarged" but I only had CLL for a year? I do take medication and all seems normal. I am not sure how my spleen is doing except it is enlarged.

November 23, 2025
A MyLeukemiaTeam Member

The Hematologist has not done any other treatments for his spleen. I am not sure if the spelling of the treatment. You may be right. I will have that clarified.

November 23, 2025
MyLeukemiaTeam

What treatments have helped manage your husband's enlarged spleen with CMML?

It sounds like you're asking about rituximab infusions (you may have meant "Rituxan" rather than "Retuxiphen"). While rituximab is commonly used for certain blood cancers, the search results don't specifically mention this treatment for CMML.

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What treatments have helped manage your husband's enlarged spleen with CMML?

It sounds like you're asking about rituximab infusions (you may have meant "Rituxan" rather than "Retuxiphen"). While rituximab is commonly used for certain blood cancers, the search results don't specifically mention this treatment for CMML.

For enlarged spleen with CMML, treatment options that have been used include:

* Radiation therapy to help shrink the spleen
* Surgical removal of the spleen (splenectomy) if other treatments don't work
* Chemotherapy drugs like Vidaza (azacitidine) or Dacogen (decitabine) to help normalize blood cell counts

CMML often leads to low white blood cell counts, which increases infection risk. Your husband's medical team may prescribe antibiotics to help prevent infections during treatment.

Since you mentioned possible lymphoma as well, his oncologist will likely tailor his treatment plan to address both conditions if confirmed. It's important to discuss the specific treatment plan and what to expect with his healthcare team, especially regarding the Wednesday infusion schedule you mentioned.

November 20, 2025

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