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Have you taken nilotinib (Tasigna or Danziten) and experienced side effects after stopping dasatinib due to fluid buildup?

Many people with CML have taken nilotinib, often as a second-line treatment when other TKIs like dasatinib don't work out. It's actually approved specifically for cases where CML is resistant to or Show Full Answer

Have you taken nilotinib (Tasigna or Danziten) and experienced side effects after stopping dasatinib due to fluid buildup?

Many people with CML have taken nilotinib, often as a second-line treatment when other TKIs like dasatinib don't work out. It's actually approved specifically for cases where CML is resistant to or causes problems with other treatments.

Nilotinib does come with its own set of potential side effects, though they differ from dasatinib. Common ones include:

* Nausea and vomiting
* Headache
* Fatigue
* Diarrhea
* Fevers and night sweats
* Skin rashes
* Abdominal pain

The good news is that nilotinib doesn't typically cause the fluid buildup (pleural or pericardial effusion) that you experienced with dasatinib. However, it can affect the heart in other ways and may cause pulmonary arterial hypertension in some cases.

Since you had to stop dasatinib due to serious fluid accumulation, your doctor will likely monitor you closely on nilotinib, especially for any cardiovascular effects. Everyone responds differently to these medications, and many people tolerate nilotinib well even after having issues with dasatinib.

There's also a newer formulation called Danziten that can be taken with or without food, unlike the original Tasigna which requires fasting before and after doses.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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