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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

On completion of targeted therapy for CLL questions:

A MyLeukemiaTeam Member asked a question 💭
Toronto, ON

I’m wondering if anyone has completed their 15 month targeted treatment for CLL with the combination Venetoclax/Calquence. How do you feel once medication is stopped? Is there improvement with fatigue, body pain, GI issues, overall wellbeing? I am nearing the end soon so would like to hear what others have experienced with their new found freedom.

November 7
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Reactions
A MyLeukemiaTeam Member

HI Elizabeth, I am on same treatment and should be done mid march, 4 more months. Can’t wait to not swallow the pills at certain times everyday. I had a 2 week delay because wbc and neutrophils got too low and I didn’t feel any different during those 2 weeks. It probably takes longer than that for the drugs to completely leave your system. I’ve had minimal side effects other than the count drop. Hope you’re doing well.

7 days ago
A MyLeukemiaTeam Member

Hopefully others who have experience will comment Elizabeth. Best to get information from a human being that has same/similar experience vs. the robot answer.

November 7
Instant Answer

What a milestone to be approaching — finishing 15 months of targeted therapy is no small thing! While specific shared experiences with the Venetoclax/Calquence combination aren't captured here, here's what's generally known about life after targeted therapy for CLL.

Many people do report gradual improvement in side effects Show Full Answer

What a milestone to be approaching — finishing 15 months of targeted therapy is no small thing! While specific shared experiences with the Venetoclax/Calquence combination aren't captured here, here's what's generally known about life after targeted therapy for CLL.

Many people do report gradual improvement in side effects after completing treatment. The timeline varies, but some key things to know:

- Fatigue can linger for 6 months to a year after treatment ends, but many people see steady improvement
- GI issues and body aches often ease as the medications clear your system
- Overall wellbeing tends to improve, though it may be gradual rather than immediate Some MyLeukemiaTeam members in remission have noted that fatigue doesn't always disappear right away, even when treatment ends. As one MyLeukemiaTeam member shared, "My CLL is in remission, but fatigue is a daily part of my life. I've learned to make the best of my fatigue-free moments."

It's worth having an open conversation with your oncologist about what to expect post-treatment, as everyone's recovery looks a little different. They can help set realistic expectations and monitor your progress closely.

November 7

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