I've been taking imbruvica for several years now. The only side effect I noticed was a tendency to dehydrate. Sports drinks easily took care of that. I think my body must've gotten used to it because I don't dehydrate anymore. As far as payment goes I have Medicare and Medicaid both. Together they take care of the financial end of things. My yearly deductible, after Medicare and Medicaid, is less than $10 for the imbruvica. Oh, and with imbruvica you're not supposed to have grapefruit. Not sure why.