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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
April 29, 2025
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With CLL, swollen lymph nodes are often persistent since they're caused by a buildup of abnormal lymphocytes in the lymph nodes. Unlike typical swollen nodes that go down on their own, CLL-related swelling may not resolve without treatment. These swollen nodes are usually painless, though some can become large enough to Show Full Answer

With CLL, swollen lymph nodes are often persistent since they're caused by a buildup of abnormal lymphocytes in the lymph nodes. Unlike typical swollen nodes that go down on their own, CLL-related swelling may not resolve without treatment. These swollen nodes are usually painless, though some can become large enough to press on nerves or organs.

If you're experiencing swollen lymph nodes, it's important to discuss this with your healthcare team as it could indicate CLL progression or need for treatment adjustment. For managing uncomfortable swollen lymph nodes from CLL, radiation therapy may be helpful in treating painful nodes. If the swelling is related to a treatment reaction (like with lenalidomide), your doctor can help adjust your treatment plan accordingly. Always report new or worsening lymph node swelling to your healthcare team, as this could be a sign that your condition needs attention.

April 29, 2025
A MyLeukemiaTeam Member

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April 30, 2025

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