T-cell LGL leukemia is a rare type of blood cancer, making up about 85% of all LGL leukemia cases. It affects white blood cells called T-cells that develop in the bone marrow and are important for fighting infections. The condition occurs in about 0.2 cases per million people per year and typically affects people between Show Full Answer
T-cell LGL leukemia is a rare type of blood cancer, making up about 85% of all LGL leukemia cases. It affects white blood cells called T-cells that develop in the bone marrow and are important for fighting infections. The condition occurs in about 0.2 cases per million people per year and typically affects people between ages 45-75. Common symptoms that others with T-cell LGL leukemia experience include:
• Low neutrophil counts (neutropenia)
• High lymphocyte counts (lymphocytosis)
• Anemia
• Low platelet counts (thrombocytopenia)
• Fever
• Night sweats
• Unintentional weight loss
• Recurrent infections
Additionally, 25-50% of people diagnosed with LGL leukemia may experience an enlarged spleen. New treatment options for LGL leukemia are continuously being developed. You may want to discuss with your doctor about potential clinical trial options that could provide access to newer treatments that may be more effective than current options.
September 12, 2025
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