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What would you like to know about chronic neutrophilic leukemia (CNL)?

CNL is an extremely rare type of leukemia - only about 200 cases have ever been found. It's a blood cancer where the bone marrow makes too many neutrophils (white blood cells that fight germs).

About 90% of people with CNL have mutations in a gene Show Full Answer

What would you like to know about chronic neutrophilic leukemia (CNL)?

CNL is an extremely rare type of leukemia - only about 200 cases have ever been found. It's a blood cancer where the bone marrow makes too many neutrophils (white blood cells that fight germs).

About 90% of people with CNL have mutations in a gene called CSF3R, which causes neutrophils to grow too quickly. This discovery has made it easier for doctors to diagnose the disease.

CNL typically affects people around age 65, with about two-thirds being male. Early on, it often doesn't cause symptoms, but later stages may bring fatigue, feeling full after eating, weight loss, fever, or general illness.

Treatment options include:
- Chemotherapy (hydroxyurea is most common)
- Immunotherapy (interferon alfa-2b)
- Targeted therapy (ruxolitinib)
- Stem cell transplant (the only potential cure)

People with CNL live an average of two years after diagnosis, though some have lived more than 20 years. About 10-20% of cases transform into acute myeloid leukemia (AML), usually within two years.

Is there something specific about CNL you'd like to understand better?

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Chronic Neutrophilic Leukemia: An Overview