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Emergency EGD found bleeding ulcer, cauterized & sutures.
Patient diagnosed with CLL in February 2026.
Would the ulcer with extensive bleeding from the colon be caused by the CLL.

June 2
 · 
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MyLeukemiaTeam

This is a really important question, and it's completely understandable to want to connect the dots between a CLL diagnosis and something as serious as a bleeding ulcer.

CLL can contribute to bleeding problems in a few key ways:

- CLL cells crowd out the bone marrow, reducing the production of platelets — the tiny cell Show Full Answer

This is a really important question, and it's completely understandable to want to connect the dots between a CLL diagnosis and something as serious as a bleeding ulcer.

CLL can contribute to bleeding problems in a few key ways:

- CLL cells crowd out the bone marrow, reducing the production of platelets — the tiny cell fragments that help blood clot and stop bleeding
- Low platelet counts (called thrombocytopenia) can cause easy bruising and significant bleeding problems
- The extreme fatigue experienced beforehand is also very consistent with CLL, as low red blood cell counts (anemia) are common So while CLL may not have directly *caused* the ulcer itself, the extensive and rapid bleeding could absolutely be connected to CLL's impact on platelet levels and the body's ability to clot blood normally.

That said, this is a critical conversation to have with the hematologist and gastroenterologist together. They can review the platelet counts around the time of the bleed and determine how much CLL contributed to the severity of the situation.

Please make sure the care team is fully aware of the CLL diagnosis when managing follow-up care — it matters a great deal for treatment decisions going forward.

June 2

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