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Yes, CML can transform into a more aggressive form. CML typically progresses through three phases:

1. Chronic phase (initial slow-growing phase where most people are diagnosed)
2. Accelerated phase (where immature white blood cells called blasts increase)
3. Blast phase

During the blast phase, CML can transform into acute Show Full Answer

Yes, CML can transform into a more aggressive form. CML typically progresses through three phases:

1. Chronic phase (initial slow-growing phase where most people are diagnosed)
2. Accelerated phase (where immature white blood cells called blasts increase)
3. Blast phase

During the blast phase, CML can transform into acute myeloid leukemia (AML), which is more aggressive and harder to treat. The transformation occurs due to genetic changes in the leukemia cells. Most CML cells contain the Philadelphia chromosome, which is created when parts of chromosomes 9 and 22 switch places. This creates the BCR-ABL1 fusion gene that produces a protein causing uncontrolled cell growth and division.

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