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A MyLeukemiaTeam Member asked a question 💭
September 9, 2025
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What causes lymph node swelling in the pelvic/groin area with CLL?

Swollen lymph nodes are one of the most common symptoms of CLL, occurring in 50-90% of cases. In CLL, abnormal lymphocytes (white blood cells) build up in the lymph nodes, causing them to swell. This commonly occurs in areas including the groin/pelvic Show Full Answer

What causes lymph node swelling in the pelvic/groin area with CLL?

Swollen lymph nodes are one of the most common symptoms of CLL, occurring in 50-90% of cases. In CLL, abnormal lymphocytes (white blood cells) build up in the lymph nodes, causing them to swell. This commonly occurs in areas including the groin/pelvic region.

The swelling is often painless, though some people experience discomfort if the nodes become large enough to press on surrounding nerves or organs. When should you talk to your doctor about swollen lymph nodes?

It's important to report swollen lymph nodes to your cancer care team as they may indicate:
- Disease progression
- Need to begin or adjust treatment
- Your CLL risk level (intermediate or high-risk)

Your healthcare team can evaluate the cause and recommend appropriate treatment options, which may include radiation for painful swollen nodes.

September 9, 2025

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