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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
November 4, 2025
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MyLeukemiaTeam

Has anyone taken Venclexta (venetoclax) for CLL along with immunotherapy, and what should you know before starting?

Yes, many people with CLL have taken Venclexta, and it's actually commonly paired with immunotherapy. A combination of Venclexta and rituximab (an immunotherapy) is a preferred treatment for relapsed or Show Full Answer

Has anyone taken Venclexta (venetoclax) for CLL along with immunotherapy, and what should you know before starting?

Yes, many people with CLL have taken Venclexta, and it's actually commonly paired with immunotherapy. A combination of Venclexta and rituximab (an immunotherapy) is a preferred treatment for relapsed or refractory CLL.

Venclexta is taken as a once-daily pill and works by targeting a specific protein that helps cancer cells survive, causing them to die.

Common side effects to be aware of include:
* Anemia (low red blood cells)
* Neutropenia (low white blood cells)
* Diarrhea
* Nausea

One important safety consideration is tumor lysis syndrome - a condition where Venclexta kills cancer cells so effectively that the contents of dead cells can potentially clog the kidneys. Because of this risk, you may need to stay in the hospital when beginning treatment or when increasing doses, so doctors can monitor you closely.

It's completely understandable to feel worried about starting a new medication. Your medical team will watch you carefully, especially in the beginning. Many people tolerate Venclexta well, and it can be especially helpful for certain types of CLL that don't respond as well to traditional chemotherapy.

Make sure to report any concerning symptoms to your doctor right away, and don't hesitate to ask questions about what to expect.

November 4, 2025
A MyLeukemiaTeam Member

I had read about taking two medications to treat CLL. I think this is a good idea? I have not read any response concerning what the dose is for each medication but I suspect the dose is lower then taking just one medication. I also suspect possible ill affects will be listed but who knows what will happen until there is more information? I think we experiment if we take medication or we we do not take medication because we do not know the ill affects until time has past for a problem to develop.

November 8, 2025

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