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Which treatment option might work better for someone who is 73 and in relatively good health with CLL: Calquence or Venclexta plus Gazyva?

Both options are effective oral therapies for CLL, and your age and overall health are important factors your doctor will consider. At 73 and in relatively good health, you may be a Show Full Answer

Which treatment option might work better for someone who is 73 and in relatively good health with CLL: Calquence or Venclexta plus Gazyva?

Both options are effective oral therapies for CLL, and your age and overall health are important factors your doctor will consider. At 73 and in relatively good health, you may be a candidate for either treatment.

Calquence (acalabrutinib):
- Taken twice daily as capsules
- Common side effects include headache, diarrhea, muscle and joint pain, infection, and irregular heartbeat
- Can cause low blood cell counts
- Requires sunscreen use due to potential skin lesions
- Often recommended for relapsed or refractory CLL, though approved for any adult with CLL

Venclexta (venetoclax) with Gazyva (obinutuzumab):
- Venclexta is taken once daily as a pill
- Side effects include anemia, neutropenia, diarrhea, and nausea
- Carries risk of tumor lysis syndrome, which may require hospitalization when starting or increasing doses
- The combination is a preferred treatment option for CLL

The best choice depends on your specific situation, including your treatment history, genetic mutations in your cancer cells, personal priorities, and how you weigh effectiveness versus potential side effects. Your oncologist can help determine which option aligns best with your health goals and individual circumstances.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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