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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLeukemiaTeam Member asked a question 💭
Lee, FL
July 23
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MyLeukemiaTeam

An enlarged spleen (splenomegaly) is pretty common with T-LGL leukemia, affecting between 25% to 50% of people diagnosed. It can make eating uncomfortable and even painful, but there are some practical ways to manage it.

Here are some tips that may help ease the discomfort:

- Eat smaller, more frequent meals throughout Show Full Answer

An enlarged spleen (splenomegaly) is pretty common with T-LGL leukemia, affecting between 25% to 50% of people diagnosed. It can make eating uncomfortable and even painful, but there are some practical ways to manage it.

Here are some tips that may help ease the discomfort:

- Eat smaller, more frequent meals throughout the day instead of large ones
- Eat slowly to give your digestive system time to process food
- Choose nutrient-dense foods like fish, nuts, and foods with healthy fats
- Try an anti-inflammatory diet to help reduce inflammation
- Avoid processed and fast foods as they can worsen inflammation
- Keep food and drinks separate — liquids can fill you up fast and make eating harder
- Try protein smoothies or powders if meat is hard to digest (a MyLeukemiaTeam member found this helpful)

As one MyLeukemiaTeam member shared, their spleen was so enlarged it had shifted out of position, causing significant pain — so you're definitely not alone in this. On the medical side, treating the spleen really comes down to managing the underlying leukemia. Doctors may recommend:

- Medications to help shrink the spleen
- Radiation therapy targeted at the spleen
- Splenectomy (surgical removal of the spleen) in some cases, which can relieve abdominal pain

One important caution — if you have an enlarged spleen, avoid contact sports or any activity that could cause abdominal trauma. A ruptured spleen is a serious medical emergency.

It's always worth looping in your care team so they can tailor the best approach for your specific situation.

July 23
A MyLeukemiaTeam Member

I had an enlarged spleen on day one of being told I had CLL. I was only told by a new doctor looking at my medical information. A year later my spleen is almost normal size. I think the medication I take has reduced my WBC count 100% normal and maybe caused my spleen to become normal in size? I hope your medication has the same affect my medication has with returning everything to normal.

July 27

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