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... Some examples of chemotherapy rarely used to treat CML include: Ara-C (cytarabine) Cytoxan (cyclophosphamide) Hydrea (hydroxyurea) Oncovin (vincristine) Synribo (omacetaxine) Chemotherapy for Chronic Lymphocytic LeukemiaThere are two main types of chemotherapy used to treat chronic lymphocytic leukemia (CLL): alkylating agents and purine analogs. ...

... If someone has CML that is refractory (resistant) to TKIs, a chemotherapy drug called Synribo (omacetaxine mepesuccinate) may help. Additionally, drugs such as Intron A (interferon alfa-2b) can be used by people who can’t take TKIs, including people who are pregnant. ...