What is the TP53 gene?
The TP53 gene is a tumor suppressor gene that provides instructions for controlling cell growth and division. It acts like a "stop" signal for cells, helping to prevent them from becoming cancerous.
When the TP53 gene works properly, it helps protect your body by
- Stopping damaged cells from Show Full Answer
What is the TP53 gene?
The TP53 gene is a tumor suppressor gene that provides instructions for controlling cell growth and division. It acts like a "stop" signal for cells, helping to prevent them from becoming cancerous.
When the TP53 gene works properly, it helps protect your body by:
- Stopping damaged cells from dividing
- Causing abnormal cells to die when they should
- Repairing damage within cells
However, when TP53 becomes mutated or changed, it can no longer perform these protective functions effectively. This allows cells to grow out of control and can lead to cancer development.
In leukemia, TP53 mutations are particularly important because they affect prognosis and treatment decisions. People with TP53 changes in their leukemia cells often have a more aggressive form of the disease and may need different treatment approaches.
TP53 mutations are found in several types of leukemia, including chronic lymphocytic leukemia (CLL), B-cell prolymphocytic leukemia (B-PLL), and acute myeloid leukemia (AML). Your doctor may test for TP53 status to help determine the best treatment plan for you.
March 4
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