I don’t know about the P190 mutation, But I know that Tasigna works for me now. I was on Sprycel for a short time, but I had to come off of it due to fluid collecting around my heart and lungs.

Hang in thete

I’m hopeful that my oncologist will be able to find a medication that works for my CMl . I know the p190 gene makes it more challenging but I try to stay positive. The fatigue is the hardest part and my arms ache constantly…

I’m also dealing with hyperthyroidism and received radio active iodine today . Isolation for 2 days.

I'm on Scemblix and doing well so far, only 2 months in.
I was ob Bosulif for 2 years and I couldn't keep food down, lost 80 lbs and almost died. No vomiting at all with the Scemblix. Some body pain, swollen lymph nodes, increased night sweats. I can deal with those side effects. Getting my first BCR test since starting Scemblix in December. Took a break between meds and it bumped me out of remission.
Everyone is different from every TKL, or so we're told.
I check on here pretty much every day, let me know if I can help. ❤️